Proteome Analysis of Human Follicular Thyroid Cancer Cells Exposed to the Random Positioning Machine

@inproceedings{Bauer2017ProteomeAO,
  title={Proteome Analysis of Human Follicular Thyroid Cancer Cells Exposed to the Random Positioning Machine},
  author={Johann Bauer and Sascha Kopp and Elisabeth Maria Schlagberger and Jirka Grosse and J. V. Sahana and Stefan Riwaldt and Markus Wehland and Ronald Luetzenberg and Manfred Infanger and Daniela Grimm},
  booktitle={International journal of molecular sciences},
  year={2017}
}
Several years ago, we detected the formation of multicellular spheroids in experiments with human thyroid cancer cells cultured on the Random Positioning Machine (RPM), a ground-based model to simulate microgravity by continuously changing the orientation of samples. Since then, we have studied cellular mechanisms triggering the cells to leave a monolayer and aggregate to spheroids. Our work focused on spheroid-related changes in gene expression patterns, in protein concentrations, and in… CONTINUE READING
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