Proteolytically activated, recombinant anti-mullerian hormone inhibits androgen secretion, proliferation, and differentiation of spermatogonia in adult zebrafish testis organ cultures.

@article{Skaar2011ProteolyticallyAR,
  title={Proteolytically activated, recombinant anti-mullerian hormone inhibits androgen secretion, proliferation, and differentiation of spermatogonia in adult zebrafish testis organ cultures.},
  author={Katrine S. Skaar and Rafael N{\'o}brega and Aristea Magaraki and Lene C. Olsen and R{\"u}diger Winfried Schulz and Axel Kulcke},
  journal={Endocrinology},
  year={2011},
  volume={152 9},
  pages={3527-40}
}
Anti-Müllerian hormone (Amh) is in mammals known as a TGFβ type of glycoprotein processed to yield a bioactive C-terminal homodimer that directs regression of Müllerian ducts in the male fetus and regulates steroidogenesis and early stages of folliculogenesis. Here, we report on the zebrafish Amh homologue. Zebrafish, as all teleost fish, do not have Müllerian ducts. Antibodies raised against the N- and C-terminal part of Amh were used to study the processing of endogenous and recombinant Amh… CONTINUE READING

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