Proteolytic requirements for thrombin activation of anti-hemophilic factor (factor VIII).

@article{Pittman1988ProteolyticRF,
  title={Proteolytic requirements for thrombin activation of anti-hemophilic factor (factor VIII).},
  author={Debra D. Pittman and Randal J Kaufman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 8},
  pages={
          2429-33
        }
}
Factor VIII functions in the intrinsic pathway of coagulation as the cofactor for factor IXa proteolytic activation of factor X. Proteolytic cleavage is required for activation and may be responsible for inactivation of cofactor activity. To identify which of the multiple cleavages are required for activation and inactivation of factor VIII, site-directed DNA-mediated mutagenesis of the factor VIII cDNA was performed and the altered forms of factor VIII were expressed in COS-1 monkey cells and… CONTINUE READING

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