Proteolytic regulation of synaptic plasticity in the mouse primary visual cortex: analysis of matrix metalloproteinase 9 deficient mice

@inproceedings{Kelly2015ProteolyticRO,
  title={Proteolytic regulation of synaptic plasticity in the mouse primary visual cortex: analysis of matrix metalloproteinase 9 deficient mice},
  author={Emily A. Kelly and Amanda S. Russo and Cory D. Jackson and Cassandra E. Lamantia and Ania K Majewska},
  booktitle={Front. Cell. Neurosci.},
  year={2015}
}
The extracellular matrix (ECM) is known to play important roles in regulating neuronal recovery from injury. The ECM can also impact physiological synaptic plasticity, although this process is less well understood. To understand the impact of the ECM on synaptic function and remodeling in vivo, we examined ECM composition and proteolysis in a well-established model of experience-dependent plasticity in the visual cortex. We describe a rapid change in ECM protein composition during Ocular… CONTINUE READING