Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity.

@article{Lei2011ProteolyticPO,
  title={Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity.},
  author={Xia Lei and Fujun Shi and Debapriya Basu and Afroza Huq and Sophie Routhier and Robert Day and Weijun Jin},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 18},
  pages={15747-56}
}
Angiopoietin-like protein 4 (ANGPTL4) has been associated with a variety of diseases. It is known as an endogenous inhibitor of lipoprotein lipase (LPL), and it modulates lipid deposition and energy homeostasis. ANGPTL4 is cleaved by unidentified protease(s), and the biological importance of this cleavage event is not fully understood with respect to its inhibitory effect on LPL activity. Here, we show that ANGPTL4 appears on the cell surface as the full-length form, where it can be released by… CONTINUE READING

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