Proteolytic processing of a protein involved in sperm-egg fusion correlates with acquisition of fertilization competence

@article{Blobel1990ProteolyticPO,
  title={Proteolytic processing of a protein involved in sperm-egg fusion correlates with acquisition of fertilization competence},
  author={Carl P Blobel and Diana Gold Myles and Paul Primakoff and Judith M White},
  journal={The Journal of Cell Biology},
  year={1990},
  volume={111},
  pages={69 - 78}
}
A protein located on the surface of guinea pig sperm (PH-30) has been implicated in the process of sperm-egg fusion (Primakoff, P., H. Hyatt, and J. Tredick-Kline. 1987. J. Cell Biol. 104:141-149). In this paper we have assessed basic biochemical properties of PH-30 and have analyzed the molecular forms of PH-30 present at different stages of sperm maturation. We show the following: (a) PH-30 is an integral membrane glycoprotein; (b) it is composed of two tightly associated and immunologically… CONTINUE READING

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