Proteolytic processing of Alzheimer's β-amyloid precursor protein.

  title={Proteolytic processing of Alzheimer's β-amyloid precursor protein.},
  author={Han Zhang and Qilin Ma and Yunwu Zhang and Huaxi Xu},
  journal={Journal of neurochemistry},
  volume={120 Suppl 1},
β-Amyloid precursor protein (APP) is a critical factor in the pathogenesis of Alzheimer's disease (AD). APP undergoes post-translational proteolysis/processing to generate the hydrophobic β-amyloid (Aβ) peptides. Deposition of Aβ in the brain, forming oligomeric Aβ and plaques, is identified as one of the key pathological hallmarks of AD. The processing of APP to generate Aβ is executed by β- and γ-secretase and is highly regulated. Aβ toxicity can lead to synaptic dysfunction, neuronal cell… CONTINUE READING