Proteolytic processing and polarized secretion of tartrate-resistant acid phosphatase is altered in a subpopulation of metaphyseal osteoclasts in cathepsin K-deficient mice.

@article{Zenger2007ProteolyticPA,
  title={Proteolytic processing and polarized secretion of tartrate-resistant acid phosphatase is altered in a subpopulation of metaphyseal osteoclasts in cathepsin K-deficient mice.},
  author={S. Zenger and Karin Hollberg and Jenny Ljusberg and Maria Norg{\aa}rd and Barbro Ek-Rylander and Riku Kiviranta and G{\"o}ran Andersson},
  journal={Bone},
  year={2007},
  volume={41 5},
  pages={820-32}
}
Tartrate-resistant acid phosphatase (TRAP) is an enzyme highly expressed in osteoclasts and thought to participate in osteoclast-mediated bone turnover. Cathepsin K (Ctsk) is the major collagenolytic cysteine proteinase expressed in osteoclasts and has recently been shown to be able to proteolytically process and activate TRAP in vitro. In this study, 4-week-old Ctsk(-/-) mice were analysed for TRAP expression at the mRNA, protein and enzyme activity levels to delineate a role of cathepsin K in… CONTINUE READING
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