Proteolytic processing and cell biological functions of the amyloid precursor protein.

Abstract

Recent research has identified some key players involved in the proteolytic processing of amyloid precursor protein (APP) to amyloid beta-peptide, the principal component of the amyloid plaques in Alzheimer patients. Interesting parallels exists with the proteolysis of other proteins involved in cell differentiation, cholesterol homeostasis and stress… (More)

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@article{Strooper2000ProteolyticPA, title={Proteolytic processing and cell biological functions of the amyloid precursor protein.}, author={Bart De Strooper and Willem Annaert}, journal={Journal of cell science}, year={2000}, volume={113 ( Pt 11)}, pages={1857-70} }