Proteolytic maturation of replicase polyprotein pp1a by the nsp4 main proteinase is essential for equine arteritis virus replication and includes internal cleavage of nsp7.

@article{Aken2006ProteolyticMO,
  title={Proteolytic maturation of replicase polyprotein pp1a by the nsp4 main proteinase is essential for equine arteritis virus replication and includes internal cleavage of nsp7.},
  author={Danny van Aken and Jessika C. Zevenhoven-Dobbe and Alexander E. Gorbalenya and Eric J. Snijder},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 12},
  pages={3473-82}
}
The positive-stranded RNA genome of the arterivirus Equine arteritis virus (order Nidovirales) encodes the partially overlapping replicase polyproteins pp1a (1727 aa) and pp1ab (3175 aa). Previously, three viral proteinases were reported to cleave these large polyproteins into 12 non-structural proteins (nsps). The chymotrypsin-like viral main proteinase residing in nsp4 is responsible for eight of these cleavages. Processing of the C-terminal half of pp1a (the nsp3-8 region) was postulated to… CONTINUE READING

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