Proteolytic inactivation of plasma C1- inhibitor in sepsis.

  title={Proteolytic inactivation of plasma C1- inhibitor in sepsis.},
  author={Jan H. Nuijens and A. J. Eerenberg-Belmer and C C Huijbregts and Willem O. Schreuder and Richelle J. F. Felt-Bersma and J. J. Abbink and Lambertus G. Thijs and C. Erik Hack},
  journal={The Journal of clinical investigation},
  volume={84 2},
Activation of both the complement system and the contact system of intrinsic coagulation is implicated in the pathophysiology of sepsis. Because C1 inhibitor (C1-Inh) regulates the activation of both cascade systems, we studied the characteristics of plasma C1-Inh in 48 patients with severe sepsis on admission to the Intensive Care Unit at the Free University of Amsterdam. The ratio between the level of functional and antigenic C1-Inh (functional index) was significantly reduced in the patients… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 56 references

Elevated plasma levels of the anaphyla - toxins C 3 a and C 4 a are associated with a fatal outcome in sepsis

  • E. R. Gaynor, L. Vitek, +5 authors S. I. Fisher
  • Am . J . Med .
  • 1989

Activation of the contact system of plasma proteolysis in the adult respiratory distress syndrome

  • J. H. Nuijens, C. C. M. Huijbregts, A. J. M. Eerenberg-Belmer, J. J. Abbink, R. J. M. Strack van Schijndel, R. J. F. Felt-Bersma
  • J . Lab . Clin . Med .
  • 1988

Inhibition of human blood coagulation factor XIa by C 1 inhibitor

  • B. N. Bouma
  • Biochemistry .
  • 1988

Interleukin - 2 induces clinical features of septic shock

  • J. H. Nuijens, C. C. M. Huijbregts, +4 authors J. C. Bakker
  • Circ . Shock .
  • 1988

The role of cachectin / TNF in endotoxic shock and cachexia

  • Y. T. Wachtfogel, R. A. Pixley, +4 authors R. W. Colman
  • Immunol . Today .
  • 1988

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