Proteolytic gene expression differs at rest and after resistance exercise between young and old women.

@article{Raue2007ProteolyticGE,
  title={Proteolytic gene expression differs at rest and after resistance exercise between young and old women.},
  author={Ulrika Raue and Dustin R. Slivka and Bozena Jemiolo and Chris Hollon and Scott W. Trappe},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2007},
  volume={62 12},
  pages={
          1407-12
        }
}
BACKGROUND Skeletal muscle atrophy in rodents is associated with increased gene expression of proteolytic markers muscle-RING-finger protein 1 (MuRF-1) and atrogin-1. In humans with age-related muscle atrophy, known as sarcopenia, little is known about these key proteolytic biomarkers. Therefore, the purpose of this investigation was 2-fold: (i) measure messenger RNA (mRNA) expression of proteolytic genes MuRF-1, atrogin-1, forkhead box (FOXO)3A, and tumor necrosis factor-alpha (TNF-alpha) in… CONTINUE READING

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