Proteolytic enzymes: a new treatment strategy for prosthetic infections?

  title={Proteolytic enzymes: a new treatment strategy for prosthetic infections?},
  author={Laura Selan and Francesca Berlutti and Claudio Passariello and M R Comodi-Ballanti and Maria Cristina Thaller},
  journal={Antimicrobial agents and chemotherapy},
  volume={37 12},
Among the different mechanisms of bacterial resistance to antimicrobial agents that have been studied, biofilm formation is one of the most widespread. This mechanism is frequently the cause of failure in the treatment of prosthetic device infections, and several attempts have been made to develop molecules and protocols that are able to inhibit biofilm-embedded bacteria. We present data suggesting the possibility that proteolytic enzymes could significantly enhance the activities of… CONTINUE READING

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