Proteolytic digestion of bacterial inclusion body proteins during dynamic transition between soluble and insoluble forms.

@article{Carri1999ProteolyticDO,
  title={Proteolytic digestion of bacterial inclusion body proteins during dynamic transition between soluble and insoluble forms.},
  author={Mar Carri{\'o} and Jos{\'e} Lu{\'i}s Corchero and Antonio Villaverde},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1434 1},
  pages={170-6}
}
Inclusion bodies formed by two closely related hybrid proteins, namely VP1LAC and LACVP1, have been compared during their building in Escherichia coli. Features of these proteins are determinant of aggregation rates and protein composition of the bodies, generating insoluble particles with distinguishable volume evolution. Interestingly, in LACVP1 and less perceptibly in VP1LAC bodies, an important fraction of the aggregated polypeptide is lost at a given stage of body construction. Stable… CONTINUE READING
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