Proteolytic degradation and impaired secretion of an apolipoprotein A-I mutant associated with dominantly inherited hypoalphalipoproteinemia.

@article{McManus2001ProteolyticDA,
  title={Proteolytic degradation and impaired secretion of an apolipoprotein A-I mutant associated with dominantly inherited hypoalphalipoproteinemia.},
  author={Dan C McManus and Bradley R Scott and Vivian Franklin and Daniel L. Sparks and Yves L. Marcel},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 24},
  pages={21292-302}
}
We have devised a combined in vivo, ex vivo, and in vitro approach to elucidate the mechanism(s) responsible for the hypoalphalipoproteinemia in heterozygous carriers of a naturally occurring apolipoprotein A-I (apoA-I) variant (Leu(159) to Arg) known as apoA-I Finland (apoA-I(FIN)). Adenovirus-mediated expression of apoA-I(FIN) decreased apoA-I and high… CONTINUE READING