Proteolytic conversion of oxytocin by brain synaptic membranes: Role of aminopeptidases and endopeptidases

@article{Stancampiano1991ProteolyticCO,
  title={Proteolytic conversion of oxytocin by brain synaptic membranes: Role of aminopeptidases and endopeptidases},
  author={R. Stancampiano and M. Melis and A. Argiolas},
  journal={Peptides},
  year={1991},
  volume={12},
  pages={1119-1125}
}
The proteolytic conversion of oxytocin and vasopressin by purified rat brain synaptic membranes was studied at 37 degrees C and physiological pH 7.4. The formed peptide fragments were isolated by high performance liquid chromatography and characterized by amino acid analysis. When oxytocin was incubated with synaptic membranes, either C- or N-terminal fragments were found. The most abundant were [Cyt6]oxytocin(4-9), [Cyt6]oxytocin(3-9), [Cyt6]oxytocin(2-9), oxytocin(1-8) and oxytocin(1-7). In… Expand
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