Proteolytic control of growth factor availability.

  title={Proteolytic control of growth factor availability.},
  author={Daniel B. Rifkin and Roberta Mazzieri and John S. Munger and Irene Noguera and Joanne Sung},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  volume={107 1},
Most growth factors are released from cells in a form that does not permit immediate interaction with their high affinity receptors. An important mechanism for presentation of these released latent growth factors is activation by the plasminogen activator-plasmin system. The involvement of this system in the biology of Transforming Growth Factor-beta (TGF-beta) is reviewed. 

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