Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif.

@article{Chang2003ProteolyticCO,
  title={Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif.},
  author={Gin-Wen Chang and Martin Stacey and Mark J. Kwakkenbos and Joerg Hamann and Siamon Gordon and Hsi-Hsien Lin},
  journal={FEBS letters},
  year={2003},
  volume={547 1-3},
  pages={145-50}
}
EMR2 is a human myeloid-restricted member of the EGF-TM7 receptor family that contains a highly conserved G protein-coupled receptor proteolysis site (GPS) in the membrane-proximal region. Here the post-translational proteolytic cleavage of EMR2 at GPS was investigated. We show the cleavage occurs at Leu517-Ser518 and is independent of the transmembrane domains. The non-covalent association of the resulting extracellular alpha-subunit and transmembrane beta-subunit requires a minimum of eight… CONTINUE READING

From This Paper

Topics from this paper.
22 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…