Proteolytic cleavage of human growth hormone (hGH) by rat tissues in vitro: influence on the kinetics of exogenously administered hGH.

@article{Wroblewski1991ProteolyticCO,
  title={Proteolytic cleavage of human growth hormone (hGH) by rat tissues in vitro: influence on the kinetics of exogenously administered hGH.},
  author={Victor J. Wroblewski and Marek Masnyk and Gerald W. Becker},
  journal={Endocrinology},
  year={1991},
  volume={129 1},
  pages={465-74}
}
The presence of several endogenous molecular forms of human GH (hGH), including proteolytically cleaved two-chain forms, has been proposed to be related to the diverse biological activity of hGH. The present study characterized hGH degradation in the rat to determine how peripheral metabolism may influence the kinetics and pharmacology of exogenously administered hGH. In vitro studies indicated that hGH was proteolytically degraded by thyroid gland and skeletal muscle, but not liver and kidney… CONTINUE READING

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