Proteolytic cleavage inactivates the Staphylococcus aureus lipoteichoic acid synthase.

@article{Wrmann2011ProteolyticCI,
  title={Proteolytic cleavage inactivates the Staphylococcus aureus lipoteichoic acid synthase.},
  author={Mirka E W{\"o}rmann and Nathalie T. Reichmann and Cheryl Malone and Alexander R. Horswill and Angelika Gr{\"u}ndling},
  journal={Journal of bacteriology},
  year={2011},
  volume={193 19},
  pages={5279-91}
}
Lipoteichoic acid (LTA) is a crucial cell envelope component in Gram-positive bacteria. In Staphylococcus aureus, the polyglycerolphosphate LTA molecule is synthesized by LtaS, a membrane-embedded enzyme with five N-terminal transmembrane helices (5TM domain) that are connected via a linker region to the C-terminal extracellular enzymatic domain (eLtaS). The LtaS enzyme is processed during bacterial growth, and the eLtaS domain is released from the bacterial membrane. Here we provide… CONTINUE READING

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