Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth.

@article{Mtt2006ProteolyticCA,
  title={Proteolytic cleavage and phosphorylation of a tumor-associated ErbB4 isoform promote ligand-independent survival and cancer cell growth.},
  author={Jorma M{\"a}{\"a}tt{\"a} and Maria Sundvall and Teemu T. Junttila and Liisa Peri and Veli Jukka O Laine and Jorma Isola and Mikala Egeblad and Klaus Elenius},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 1},
  pages={
          67-79
        }
}
The ErbB1 and ErbB2 receptors are oncogenes with therapeutic significance in human cancer, whereas the transforming potential of the related ErbB4 receptor has remained controversial. Here, we have addressed whether four alternatively spliced ErbB4 isoforms differ in regulating cellular responses relevant for tumor growth. We show that the two tumor necrosis factor-alpha converting enzyme (TACE)-cleavable ErbB4 isoforms (the juxtamembrane [JM]-a isoforms) were overexpressed in a subset of… CONTINUE READING
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