Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases.

@article{Chen2015ProteolyticCT,
  title={Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases.},
  author={Mei-Kuang Chen and Mien-Chie Hung},
  journal={The FEBS journal},
  year={2015},
  volume={282 19},
  pages={3693-721}
}
Intracellular localization has been reported for over three-quarters of receptor tyrosine kinase (RTK) families in response to environmental stimuli. Internalized RTK may bind to non-canonical substrates and affect various cellular processes. Many of the intracellular RTKs exist as fragmented forms that are generated by γ-secretase cleavage of the full… CONTINUE READING