Proteolytic cascade enzymes increase in focal cerebral ischemia in rat.

  title={Proteolytic cascade enzymes increase in focal cerebral ischemia in rat.},
  author={Gary A Rosenberg and Milan Navr{\'a}til and Francesca Barone and Giora Feuerstein},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={16 3},
Cerebral infarction initiates a cascade of molecular events, leading to proteolytic cell death. Matrix-degrading metalloproteinases (MMPs) are neutral proteases involved in extracellular matrix damage. Type IV collagenase is an MMP that increases cerebral capillary permeability after intracerebral injection and may be important along with plasminogen activators (PA) in secondary brain edema in stroke. Therefore, we measured MMPs and PAs in spontaneously hypertensive (SHR) or Wistar-Kyoto (WKY… CONTINUE READING
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