Proteolytic activity is involved in changes in intrafollicular insulin-like growth factor-binding protein levels during growth and atresia of ovine ovarian follicles.

@article{Besnard1996ProteolyticAI,
  title={Proteolytic activity is involved in changes in intrafollicular insulin-like growth factor-binding protein levels during growth and atresia of ovine ovarian follicles.},
  author={Nathalie Besnard and Claudine Pisselet and Juergen Zapf and William G Hornebeck and Danielle Monniaux and Philippe Monget},
  journal={Endocrinology},
  year={1996},
  volume={137 5},
  pages={1599-607}
}
In the sheep, follicular growth is characterized by both an increase and a decrease in the level of intrafollicular insulin-like growth factor-binding protein-3 (IGFBP-3) and IGFBPs less than 40 kDa (IGFBP-2, -4, and -5), respectively. In contrast, follicular atresia is associated with a decrease and a large increase in levels of IGFBP-3 and IGFBPs less than 40 kDa, respectively. To assess whether intrafollicular proteases are involved in such changes, follicular fluid from follicles of… CONTINUE READING

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