Proteolytic activation of the precursor of membrane type 1 matrix metalloproteinase by human plasmin. A possible cell surface activator.

@article{Okumura1997ProteolyticAO,
  title={Proteolytic activation of the precursor of membrane type 1 matrix metalloproteinase by human plasmin. A possible cell surface activator.},
  author={Yuushi Okumura and Hiroshi Sato and Motoharu Seiki and Hiroshi Kido},
  journal={FEBS letters},
  year={1997},
  volume={402 2-3},
  pages={
          181-4
        }
}
Membrane type 1 matrix metalloproteinase (MT1-MMP) was suggested to play a critical role in the regulation of tissue invasion by normal and neoplastic cells by directly mediating the activation of pro-gelatinase A. Recently, the proteolytic activation of a pro-MT1-MMP by an intracellular proprotein convertase, furin, was reported. In this study, we found that plasmin efficiently activates the pro-MT1-MMP by cleaving immediately downstream of Arg108 and Arg111 in the multi-basic motif between… CONTINUE READING
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