Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

@article{Emoto1995ProteolyticAO,
  title={Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.},
  author={Yutaka Emoto and Yoshinobu Manome and Gerold Meinhardt and Hiroshi Kisaki and Surender Kharbanda and Mark Robertson and Tariq Ghayur and Winnie Wing-Yin Wong and Robert Kamen and Ralph Weichselbaum},
  journal={The EMBO journal},
  year={1995},
  volume={14 24},
  pages={6148-56}
}
These studies demonstrate that treatment of human U-937 cells with ionizing radiation (IR) is associated with activation of a cytoplasmic myelin basic protein (MBP) kinase. Characterization of the kinase by gel filtration and in-gel kinase assays support activation of a 40 kDa protein. Substrate and inhibitor studies further support the induction of protein kinase C (PKC)-like activity. The results of N-terminal amino acid sequencing of the purified protein demonstrate identity of the kinase… CONTINUE READING
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