Proteolytic activation and function of the cytokine Spätzle in the innate immune response of a lepidopteran insect, Manduca sexta.

@article{An2010ProteolyticAA,
  title={Proteolytic activation and function of the cytokine Sp{\"a}tzle in the innate immune response of a lepidopteran insect, Manduca sexta.},
  author={Chunju An and Haobo Jiang and Michael R. Kanost},
  journal={The FEBS journal},
  year={2010},
  volume={277 1},
  pages={148-62}
}
The innate immune response of insects includes induced expression of genes encoding a variety of antimicrobial peptides. The signaling pathways that stimulate this gene expression have been well characterized by genetic analysis in Drosophila melanogaster, but are not well understood in most other insect species. One such pathway involves proteolytic activation of a cytokine called Spätzle, which functions in dorsal-ventral patterning in early embryonic development and in the antimicrobial… CONTINUE READING