Proteolytic Activity of the 26S Proteasome Is Required for the Meiotic Resumption, Germinal Vesicle Breakdown, and Cumulus Expansion of Porcine Cumulus-Oocyte Complexes Matured In Vitro1

@inproceedings{Yi2008ProteolyticAO,
  title={Proteolytic Activity of the 26S Proteasome Is Required for the Meiotic Resumption, Germinal Vesicle Breakdown, and Cumulus Expansion of Porcine Cumulus-Oocyte Complexes Matured In Vitro1},
  author={Young-Joo Yi and Eva Nagyov{\'a} and Gaurishankar Manandhar and Radek Proch{\'a}zka and Miriam Sutovsky and Chang-Sik Park and Peter Sutovsky},
  booktitle={Biology of reproduction},
  year={2008}
}
Abstract The resumption of oocyte meiosis in mammals encompasses the landmark event of oocyte germinal vesicle (GV) breakdown (GVBD), accompanied by the modification of cell-to-cell communication and adhesion between the oocyte and surrounding cumulus cells. The concomitant cumulus expansion relies on microfilament-cytoskeletal remodeling and extracellular matrix (ECM) deposition. We hypothesized that this multifaceted remodeling event requires substrate-specific proteolysis by the ubiquitin… Expand
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  • E. Nagyová
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