Proteolysis of neuronal cell adhesion molecule by the tissue plasminogen activator–plasmin system after kainate injection in the mouse hippocampus

@article{Endo1999ProteolysisON,
  title={Proteolysis of neuronal cell adhesion molecule by the tissue plasminogen activator–plasmin system after kainate injection in the mouse hippocampus},
  author={Akira Endo and Nobuo Nagai and Tetsumei Urano and Yumiko Takada and Akikazu Takada},
  journal={Neuroscience Research},
  year={1999},
  volume={33},
  pages={1-8}
}
Tissue plasminogen activator (tPA) is a serine protease that converts inactive plasminogen to the active protease plasmin and mediates extracellular metabolism. tPA is transcriptionally induced in the mouse hippocampus by pharmacological or electrical stimulation of neuronal activity and mediates excitotoxin-induced neuronal degeneration. Therefore, we hypothesized that tPA would be induced in the hippocampus after kainic acid (KA) injection into the lateral cerebral ventricle (LCV) and that… CONTINUE READING

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