Proteolysis and the biochemistry of life-or-death decisions

A Poptosis, the process by which cells commit suicide, is ubiquitous in both normal and diseased tissues, and its mechanism is conserved in animal species from humans at least to nematodes. Apoptotic cells undergo a stereotypical set of changes--shrinkage, cleavage of nuclear DNA, condensation of chromatin, fragmentation of the cytoplasm-that distinguish… CONTINUE READING

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