Proteolysis and class I major histocompatibility complex antigen presentation

  title={Proteolysis and class I major histocompatibility complex antigen presentation},
  author={I. York and A. Goldberg and X. Mo and K. Rock},
  journal={Immunological Reviews},
  • I. York, A. Goldberg, +1 author K. Rock
  • Published 1999
  • Biology, Medicine
  • Immunological Reviews
  • Summary: The class I major histocompatibility complex (MHC class 1) presents 8–10 residue peptides to cytotoxic T lymphocytes. Most of these antigenic peptides are generated during protein degradation in the cytoplasm and are then transported into the endoplasmic reticulum by the transporter associated with antigen processing (TAP), Several lines of evidence have indicated that the proteasome is the major proteolytic activity responsible for generation of antigenic peptides—probably most… CONTINUE READING
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