Proteolysis and class I major histocompatibility complex antigen presentation.

@article{York1999ProteolysisAC,
  title={Proteolysis and class I major histocompatibility complex antigen presentation.},
  author={Ian A. York and Alfred L Goldberg and Xiaokang Mo and Kenneth L. Rock},
  journal={Immunological reviews},
  year={1999},
  volume={172},
  pages={
          49-66
        }
}
The class I major histocompatibility complex (MHC class I) presents 8-10 residue peptides to cytotoxic T lymphocytes. Most of these antigenic peptides are generated during protein degradation in the cytoplasm and are then transported into the endoplasmic reticulum by the transporter associated with antigen processing (TAP). Several lines of evidence have indicated that the proteasome is the major proteolytic activity responsible for generation of antigenic peptides--probably most conclusive has… CONTINUE READING

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