Proteolysis and chaperones: the destruction/reconstruction dilemma.

Abstract

Cytoplasmic proteases, although necessary for proper cell functioning, must be strictly regulated. In fact, they resemble chaperones, ancient protein folding devices. These molecules recognise exposed hydrophobic regions of unfolded or denatured proteins. For most substances it is not known how the cell chooses between the refolding and proteolytic pathways… (More)

Topics

  • Presentations referencing similar topics