Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle.

@article{Yew1997ProteolysisAD,
  title={Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle.},
  author={P. Yew and Marc W Kirschner},
  journal={Science},
  year={1997},
  volume={277 5332},
  pages={1672-6}
}
The cell division cycle gene, CDC34, is required for ubiquitin-mediated degradation of G1 regulators and cell cycle progression through the transition from G1 to S phase in budding yeast. A CDC34 requirement for S phase onset in higher eukaryotes has not been established. Studies of the simple embryonic cell cycle of Xenopus laevis eggs demonstrated that Cdc34p in a large molecular size complex was required in the initiation of DNA replication. Cdc34p appears to regulate the initiation function… CONTINUE READING