Proteolysis: from the lysosome to ubiquitin and the proteasome

@article{Ciechanover2005ProteolysisFT,
  title={Proteolysis: from the lysosome to ubiquitin and the proteasome},
  author={Aaron Ciechanover},
  journal={Nature Reviews Molecular Cell Biology},
  year={2005},
  volume={6},
  pages={79-87}
}
How the genetic code is translated into proteins was a key focus of biological research before the 1980s, but how these proteins are degraded remained a neglected area. With the discovery of the lysosome, it was suggested that cellular proteins are degraded in this organelle. However, several independent lines of experimental evidence strongly indicated that non-lysosomal pathways have an important role in intracellular proteolysis, although their identity and mechanisms of action remained… CONTINUE READING
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