Proteolysis: anytime, any place, anywhere?

  title={Proteolysis: anytime, any place, anywhere?},
  author={Jonathon Pines and Catherine Lindon},
  journal={Nature Cell Biology},
Proteolysis via the ubiquitin–proteasome system (UPS) is a rapid and effective method of degrading a specific protein at a specific time, and in many cases a protein is degraded only in response to a particular cellular signal or event. However, an added dimension to the control of protein degradation is possible because the ubiquitin system can be spatially regulated. Controlling where a protein is degraded can enhance the specificity and timing of proteolysis, generate asymmetry and maintain… CONTINUE READING

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