Proteoglycans on bone tumor development.

  title={Proteoglycans on bone tumor development.},
  author={Carmen Ruiz Velasco and Sylvia Colliec-Jouault and Françoise R{\'e}din{\'i} and Dominique Heymann and Marc Padrines},
  journal={Drug discovery today},
  volume={15 13-14},
Proteoglycans, extracellular matrix components, exert several activities on bone cells and seem crucial for maintaining an appropriate number of osteoblasts and osteoclasts. The overall data strengthen a pro-bone resorptive role for proteoglycans, through the control of osteoprotegerin availability and of receptor activator of NF-kappaB ligand bioactivity. In parallel, proteoglycans participate in the control of tumor development at different levels, including bone tumor development and bone… CONTINUE READING


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