Proteoglycans of basement membranes.

@article{Timpl1993ProteoglycansOB,
  title={Proteoglycans of basement membranes.},
  author={Rupert Timpl},
  journal={Experientia},
  year={1993},
  volume={49 5},
  pages={417-28}
}
Proteoglycans carrying either heparan sulfate and/or chondroitin sulfate side chains are typical constituents of basement membranes. The most prominent proteoglycan (perlecan) consists of a 400-500 kDa core protein and three heparan sulfate chains. Electron microscopy and cDNA sequencing show a complex and elongated domain structure for the core protein which in part is homologous to that of the laminin A chain. This structure may be varied by alternative splicing and proteolysis. Integration… CONTINUE READING

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