Proteoglycans in health and disease: the multiple roles of syndecan shedding.

@article{ManonJensen2010ProteoglycansIH,
  title={Proteoglycans in health and disease: the multiple roles of syndecan shedding.},
  author={Tina Manon-Jensen and Yoshifumi Itoh and John R Couchman},
  journal={The FEBS journal},
  year={2010},
  volume={277 19},
  pages={
          3876-89
        }
}
Proteolytic processes in the extracellular matrix are a major influence on cell adhesion, migration, survival, differentiation and proliferation. The syndecan cell-surface proteoglycans are important mediators of cell spreading on extracellular matrix and respond to growth factors and other biologically active polypeptides. The ectodomain of each syndecan is constitutively shed from many cultured cells, but is accelerated in response to wound healing and diverse pathophysiological events… CONTINUE READING

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