Proteoglycans as Target for an Innovative Therapeutic Approach in Chondrosarcoma: Preclinical Proof of Concept.

@article{Peyrode2016ProteoglycansAT,
  title={Proteoglycans as Target for an Innovative Therapeutic Approach in Chondrosarcoma: Preclinical Proof of Concept.},
  author={Caroline Peyrode and Val{\'e}rie Weber and Aur{\'e}lien Voissi{\`e}re and Aur{\'e}lie Maisonial-Besset and Aur{\'e}lien Vidal and Philippe Auzeloux and Vincent Gaumet and Mich{\`e}le Borel and M M Dauplat and Mercedes Quintana and Françoise Degoul and Françoise R{\'e}din{\'i} and J M Chezal and Elisabeth Miot-Noirault},
  journal={Molecular cancer therapeutics},
  year={2016},
  volume={15 11},
  pages={2575-2585}
}
To date, surgery remains the only option for the treatment of chondrosarcoma, which is radio- and chemoresistant due in part to its large extracellular matrix (ECM) and poor vascularity. In case of unresectable locally advanced or metastatic diseases with a poor prognosis, improving the management of chondrosarcoma still remains a challenge. Our team… CONTINUE READING