Proteoglycans and glycosaminoglycans synthesized in vitro by mesangial cells from normal and diabetic rats.

@article{Hadad1996ProteoglycansAG,
  title={Proteoglycans and glycosaminoglycans synthesized in vitro by mesangial cells from normal and diabetic rats.},
  author={S J Hadad and Y M C da Silva Michelacci and Nestor Schor},
  journal={Biochimica et biophysica acta},
  year={1996},
  volume={1290 1},
  pages={18-28}
}
In the renal glomerulus, two extracellular matrices have been identified, the glomerular basement membrane and the mesangial matrix. Accumulation of glomerular extracellular matrix is a conspicuous feature of most forms of progressive glomerular disease, including diabetic nephropathy. Since proteoglycans are prominent components of the extracellular matrix, we examined the glycosaminoglycans and proteoglycans synthesized in vitro by mesangial cells from normal and diabetic rats. A mixture of… CONTINUE READING