Proteoglycan production is required in initial stages of new cartilage matrix formation but inhibits integrative cartilage repair.

@article{BastiaansenJenniskens2009ProteoglycanPI,
  title={Proteoglycan production is required in initial stages of new cartilage matrix formation but inhibits integrative cartilage repair.},
  author={Yvonne Maria Bastiaansen-Jenniskens and Wendy J. L. M. Koevoet and Carola Feijt and Pieter Koen Bos and Jan A. N. Verhaar and Gerjo J. V. M. van Osch and Jeroen Degroot},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2009},
  volume={3 2},
  pages={117-23}
}
The optimal stimulus to repair or regenerate cartilage is not known. We therefore modulated collagen deposition, collagen crosslinking and GAG deposition simultaneously during cartilage matrix production and integrative repair, creating more insight into their role in cartilage repair processes. Insulin-like growth factor 1 (IGF-1; increases proteoglycan… CONTINUE READING