Proteoglycan-mediated inhibition of A beta proteolysis. A potential cause of senile plaque accumulation.

@article{GuptaBansal1995ProteoglycanmediatedIO,
  title={Proteoglycan-mediated inhibition of A beta proteolysis. A potential cause of senile plaque accumulation.},
  author={R Gupta-Bansal and Robert C. A. Frederickson and Kurt R. Brunden},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 31},
  pages={18666-71}
}
Senile plaques of Alzheimer's disease brain contain, in addition to beta amyloid peptide (A beta), multiple proteoglycans. Systemic amyloidotic deposits also routinely contain proteoglycan, suggesting that these glycoconjugates are generally involved in amyloid plaque formation and/or persistence. We demonstrate that heparan sulfate proteoglycan (HSPG) and chondroitin sulfate proteoglycan (CSPG) inhibit the proteolytic degradation of fibrillar, but not non-fibrillar, A beta at physiological pH… CONTINUE READING