Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology.

  title={Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology.},
  author={Tibor T. Glant and Katalin Mikecz and Artin Arzoumanian and A. Robin Poole},
  journal={Arthritis and rheumatism},
  volume={30 2},
Immunization with chondroitinase ABC-digested fetal human cartilage proteoglycan and Freund's complete adjuvant induced polyarthritis and ankylosing spondylitis in female BALB/c mice. The initial external symptoms of the joint inflammation were swelling and redness. This was associated with edema of the synovium and periarticular tissues and gross proliferation of cells, which reached a peak during weeks 7-9 of the experiment. Mononuclear cell infiltration, with perivascular concentration and… CONTINUE READING


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