Proteoglycan fragmentation and respiratory mechanics in mechanically ventilated healthy rats.

@article{Moriondo2007ProteoglycanFA,
  title={Proteoglycan fragmentation and respiratory mechanics in mechanically ventilated healthy rats.},
  author={Andrea Moriondo and Paolo Pelosi and Alberto Passi and Manuela Viola and Cristiana Marcozzi and Paolo Severgnini and Vittoria Ottani and Marilisa Quaranta and Daniela Negrini},
  journal={Journal of applied physiology},
  year={2007},
  volume={103 3},
  pages={747-56}
}
This research investigated whether stretching of lung tissue due to increased positive alveolar pressure swings during mechanical ventilation (MV) at various tidal volumes (V(T)) might affect the composition and/or structure of the glycosaminoglycan (GAG) components of pulmonary extracellular proteoglycans. Experiments were performed in 30 healthy rats: 1) anesthetized and immediately killed (controls, C-0); 2) anesthetized and spontaneously breathing for 4 h (C-4h); and 3) anesthetized… CONTINUE READING
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Matrix proteoglycans in development of pulmonary edema

  • D Negrini, A Passi, G De Luca, G. Miserocchi
  • J Appl Physiol
  • 2007

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