Proteoglycan expression in the normal rat kidney.

@article{Pyke1997ProteoglycanEI,
  title={Proteoglycan expression in the normal rat kidney.},
  author={Christopher Pyke and Peter Norskov Kristensen and Per B Ostergaard and Peter Sandor Oturai and J Jonh R{\o}mer},
  journal={Nephron},
  year={1997},
  volume={77 4},
  pages={
          461-70
        }
}
Proteoglycans constitute a heterogenous group of complex macromolecules, consisting of a backbone core protein and a variable number of sulfated polysaccharide side chains covalently linked to the core. A dual function for these polyanionic glycosaminoglycans in kidney physiology has been proposed: to maintain a fixed negative charge in the glomerular filtration barrier, and to bind and sequester cytokines essential for renal development and function. With the aim of identifying proteoglycan… CONTINUE READING
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