Proteoglycan depletion alone is not sufficient to stimulate proteoglycan synthesis in cultured bovine cartilage explants.

@article{Lee1994ProteoglycanDA,
  title={Proteoglycan depletion alone is not sufficient to stimulate proteoglycan synthesis in cultured bovine cartilage explants.},
  author={Dong Hoon Lee and George Bentley and Charles William Archer},
  journal={Osteoarthritis and cartilage},
  year={1994},
  volume={2 3},
  pages={
          175-85
        }
}
Articular cartilage comprises a small number of cells embedded within a matrix primarily composed of collagen and proteoglycan (PG). The functional integrity of the tissue is highly dependent on the maintenance of matrix structure, which, in turn, is controlled by the chondrocytes. In normal tissue there is a slow but steady turnover of matrix components such that their levels remain constant. In certain diseased states the equilibrium is upset, resulting in a net loss of matrix components. The… CONTINUE READING