Proteoglycan 4 expression protects against the development of osteoarthritis.

  title={Proteoglycan 4 expression protects against the development of osteoarthritis.},
  author={Merry Z C Ruan and Ayelet Erez and Kilian Guse and B. R. P. Dawson and Terry K. Bertin and Yuqing Chen and Ming-Ming Jiang and Jason Yustein and Francis Gannon and Brendan Lee},
  journal={Science translational medicine},
  volume={5 176},
Osteoarthritis (OA) is a common degenerative condition that afflicts more than 70% of the population between 55 and 77 years of age. Although its prevalence is rising globally with aging of the population, current therapy is limited to symptomatic relief and, in severe cases, joint replacement surgery. We report that intra-articular expression of proteoglycan 4 (Prg4) in mice protects against development of OA. Long-term Prg4 expression under the type II collagen promoter (Col2a1) does not… CONTINUE READING
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