Proteoglycan:collagen interactions and subfibrillar structure in collagen fibrils. Implications in the development and ageing of connective tissues.

@article{Scott1990ProteoglycancollagenIA,
  title={Proteoglycan:collagen interactions and subfibrillar structure in collagen fibrils. Implications in the development and ageing of connective tissues.},
  author={J. E. Scott},
  journal={Journal of anatomy},
  year={1990},
  volume={169},
  pages={23-35}
}
Evidence is presented confirming that collagen fibrils are aggregates of subfibrils. Rat tail tendon fibrils swollen in acetate buffer, pH 5.8, (with or without MgCl2 or Cupromeronic blue, a proteoglycan (PG) precipitant used to locate PGs by electron histochemistry) showed two characteristic populations of subfibrils, of 10-15 nm, and approximately 25 nm thickness respectively. The smaller protofibrils, helically orientated, were derived from, or coalesced into, the larger subfibrils. The… CONTINUE READING

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