Proteogenomics connects somatic mutations to signaling in breast cancer

  title={Proteogenomics connects somatic mutations to signaling in breast cancer},
  author={Philipp Mertins and D. R. Mani and Kelly V Ruggles and Michael A. Gillette and Karl R. Clauser and Pei Xin Wang and Xianlong Wang and Jana W. Qiao and Song Cao and Francesca Petralia and Emily Kawaler and Filip Mundt and Karsten Krug and Zhidong Tu and Jonathan T Lei and Michael L. Gatza and Matthew Wilkerson and Charles M. Perou and Venkata Yellapantula and Kuan-Lin Huang and ChenWei Lin and Michael D. McLellan and Ping Wang Yan and Sherri R Davies and R. Reid Townsend and Steven J. Skates and Jing Wang and Bing Zhang and Christopher R. Kinsinger and Mehdi Mesri and Henry Rodriguez and Li Ding and Amanda G. Paulovich and David Fenyő and Matthew J. Ellis and Steven A. Carr},
Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly understood. Here we describe quantitative mass-spectrometry-based proteomic and phosphoproteomic analyses of 105 genomically annotated breast cancers, of which 77 provided high-quality data. Integrated… CONTINUE READING