Proteogenomics: needs and roles to be filled by proteomics in genome annotation.

  title={Proteogenomics: needs and roles to be filled by proteomics in genome annotation.},
  author={Charles Ansong and Samuel Owen Purvine and Joshua N. Adkins and Mary S. Lipton and Richard D. Smith},
  journal={Briefings in functional genomics & proteomics},
  volume={7 1},
While genome sequencing efforts reveal the basic building blocks of life, a genome sequence alone is insufficient for elucidating biological function. Genome annotation--the process of identifying genes and assigning function to each gene in a genome sequence--provides the means to elucidate biological function from sequence. Current state-of-the-art high-throughput genome annotation uses a combination of comparative (sequence similarity data) and non-comparative (ab initio gene prediction… CONTINUE READING

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